Document Type : Review article
Authors
1
M.B. B.Ch. 2015, Faculty of Medicine, Suez Canal University, Assistant Lecturer of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Egypt.
2
Lecturer of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Egypt.
3
Assistant Professor of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Egypt.
4
Professor of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Egypt.
5
Professor of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University, Egypt.
Abstract
Acute pancreatitis (AP) is an inflammatory disorder of the pancreas with a wide clinical spectrum ranging from mild, self-limiting symptoms to severe necrotizing disease with multi-organ failure. It remains a significant health burden globally, commonly triggered by gallstones and excessive alcohol intake. Pathophysiologically, AP arises from premature activation of pancreatic enzymes, particularly trypsin, leading to autodigestion, inflammation, and tissue damage. Despite advancements in understanding its etiology and pathogenesis, specific treatments for AP remain limited, with current management focused on supportive care. In recent years, nanotechnology has emerged as a promising approach for improving diagnostics and therapeutics in numerous biomedical applications, including AP. Nanoparticles possess unique physicochemical properties that enhance drug solubility, bioavailability, and targeted delivery, minimizing systemic toxicity. Furthermore, nano-antioxidants such as selenium nanoparticles have demonstrated potential in mitigating oxidative stress, a key contributor to pancreatic injury. Nanotechnology enables innovative strategies for early detection, controlled drug delivery, and modulation of inflammatory responses in AP. This review highlights the pathophysiology and clinical implications of AP and explores the expanding role of nanotechnology in enhancing diagnostic accuracy and therapeutic efficacy. Emphasis is placed on the mechanisms through which nanoparticles exert protective effects on pancreatic tissue and their potential integration into standard clinical practice. Continued research into nano-based interventions offers promising prospects for the development of targeted, efficient, and less invasive treatment modalities for acute pancreatitis.
Keywords
Main Subjects
)
View on SCiNiTO