Role of Long non-coding RNA Gene Expression in Breast Cancer

Mohammed, Dalia Abdelnasser Awad; Elzawawy, Ahmed Mostafa; Abdullah, Hoda Yousry; Atef, Mahinour Mohamed; Abdel Salam, Lubna Omar El-Farouk; Shafik, Hanan Ezzat

doi:10.21608/ermhs.2025.416624.1068

Role of Long non-coding RNA Gene Expression in Breast Cancer

Document Type : Review article

Authors

¹ MBBCh, M.S.C, Assistant-Lecturer of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University.

² Professor of Clinical Oncology, Faculty of Medicine, Suez Canal University.

³ Assistant Professor of Medical Genetics, Faculty of Medicine, Suez Canal University.

⁴ Lecturer of Clinical Oncology, Faculty of Medicine, Suez Canal University.

⁵ Professor Of Pathology, Faculty Of Medicine, Cairo University.

⁶ Professor of Medical Oncology NCI Cairo university.

10.21608/ermhs.2025.416624.1068

Abstract

One of the most prevalent illnesses in women, breast cancer is thought to be a complex and diverse condition that continues to be a significant public health issue. Long non-coding RNAs have drawn a lot of interest lately because of the advancement of next-generation sequencing methods. Long non-coding RNAs have been shown in several studies to play significant roles in the formation of tumors. Recent studies have shown that a variety of long non-coding RNAs express aberrantly in malignancies, including breast cancer, despite the fact that the biological role and molecular processes of these RNAs are still unknown. With an emphasis on the many molecular functions of regulatory long non-coding RNAs that control cell proliferation, invasion, metastasis, and apoptosis, we have included the most recent research on long non-coding RNAs in breast cancer here.
One of the most prevalent illnesses in women, breast cancer is thought to be a complex and diverse condition that continues to be a significant public health issue. Long non-coding RNAs have drawn a lot of interest lately because of the advancement of next-generation sequencing methods. Long non-coding RNAs have been shown in several studies to play significant roles in the formation of tumors. Recent studies have shown that a variety of long non-coding RNAs express aberrantly in malignancies, including breast cancer, despite the fact that the biological role and molecular processes of these RNAs are still unknown.

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